St. Gregory’s High School established by Rev. Father Gregory De Groote, a Benedictine Priest in January 1882 set many historical records towards its journey of education as well as humanitarian activities.  

The school came into being with a handful of boys. But soon school had to be closed down twice. The school resumed then in 1889 and Father Francis Boeres CSC took the charge of the school. Within twenty years, he set the school upon its solid foundation by his untiring efforts. The school was initially used to teach only Eurasian and European children. Indian students were only allowed under special permission and that was only fifteen percent. In 1898 there were six Bengali boys and two Bengali girls among the students. In 1912 the girls section was separated from the boys and St. Francis Xavier’s came into existence.

In 1924 Board’s recognition was granted and in 1928 six boys were sent for high school exam and all came out with good results. In 1934 Dalim Guha topped the list in the board exam. He was one of the best products of St. Gregory’s High School. He also stood first in ISC and stood First Class First in BSC with Honors in Physics from Calcutta University in 1938. In the same year his friend Protap Chandra stood third in the board Examination with letter marks in English, a very rare event. He also got a record of getting 97 percent marks in History from the Board of Intermediate, Calcutta University. In 1936, 37, 38 Nirmal Chandra Basu Roy, Jatindralal Das, Abdur Rouf, stood First in the Board Examination respectively. In 1941 Ashim Kumar Mukherjee came first in merit. After three years (1944) St. Gregory’s boys got 6 positions in the merit list including the first and second position occupied by Tarak Das and Arun kumar Basak respectively. Tajuddin Ahmed the First Prime Minister of Bangladesh secured 12th place in the merit list.

In the year 1947 the first, second and third position in the merit list were  captured by , Nirmal Chakraborty, AQM Badruddoza Chowdhury, the 13th President of the People’s Republic of Bangladesh and Samir Sen respectively.